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Beer 中心转抄来的关于丈夫DQ alpha 201的资料
4 k; X5 S) ]2 \. o; X"A. DQ Alpha
# k# g' h3 k4 @- Q! rThis test measures whether the DNA of the couple is too closely matched. These tests give you! t6 ]: D! f- A7 _
back two numbers for both members of the couple. In a normal pregnancy the father's DNA in+ x4 f* y( Q0 K4 ~$ |% W
the baby tells the mother's body to set up a protective reaction around the developing embryo. If
2 q( W3 b8 x" D: d) ithe father's DNA is too closely matched to the mother's, there is a good chance that the embryo! a D) o% Q1 u/ h) R9 r
created by them is unable to differentiate itself from the mother's body. The mother's body then
/ a% @; H# `- U4 M- @0 trejects the embryo because it cannot identify the embryo as a baby.0 v1 J# _$ n) P
There are two different tests for the DQ, the Alpha and the Beta test. Most patients are only
8 B) n. ?/ O5 ytested for the Alpha. The mother-to-be and the father-to-be get back two numbers (1.1, 1.2, 1.3,6 `3 z$ S# l0 J: i: m
1.4, 2, 3 or 4) one each from each of their respective parents (the baby-to-be's grandparents).3 ^- X. p( ], k$ s
Although there are breakdowns of the 2's, 3's and 4's, many people find that only the 1's are
* o/ z. P D0 u' Q, R# w/ n7 wsignificant, so they break those down to one more decimal. If both the mother-to-be's and the
+ n5 I; M p& w mfather-to-be's DQ Alpha come back with a 4 DQ Alpha or the father-to-be's DQ Alpha comes
3 Q( o( B7 W6 o0 [& P, Nback with a 2, a DQ Beta test is run. A DQ Alpha 2 translates into a DQ Alpha 201. The DQ" I4 l% |4 J% \6 T2 x
molecule also has a beta chain, and when the DQ Beta is 201, then this sperm will only produce$ S' r* x. J" o, F- T; K2 {
a placenta, and not a baby. 89% of the people who test APA positive either have DQ Alpha 4 or
$ _+ B! l3 i$ q3 ^( D- G2 \closely matched DQ Alphas between partners. DQ Alpha compatibility is seen between mother
3 w3 Y3 n$ t' A4 L! g# `and pregnancies that failed (through IVF failure or recurrent pregnancy loss). DQ incompatibility6 @1 _$ t E- Z! b9 e/ o2 P1 X8 T
between mother and baby was far more common in women successfully delivering babies.7 n! c/ V! o: h0 c1 e3 W& z
DQ 201: If the father-to-be has a 2 in his DQ Alpha, 2% of the time a DQ Beta will show that it
1 U8 ^ G$ o) @2 h1 F2 t+ T1 e( }is also a DQ 201. Since the DQ 201 father-to-be has two DQ numbers, if only one of his, H1 g6 |6 e. i# B' y6 e* F0 K
numbers is the DQ 201, he has a 50/50 chance of producing an embryo that is DQ 201. If both of
0 h0 c* m# P2 K6 fhis numbers, both Alpha and Beta come back as 201, he has a 100% chance that all of his
$ F; z# z" O( b1 g% ~* n8 |5 v4 R( T/ gembryos will become blighted ova. The cure for this, when only one of his numbers is 201, is to+ k7 i+ H, Q) U* _$ U& G0 A) g5 v4 z
put back more embryos to see if you can produce an embryo that is not DQ 201. If he has both
0 z+ o* {& b4 q& e' y- Pnumbers come back as a 201, the only option is donor sperm. 100% of DQ 201 embryos become" X( y) Q' g! @
blighted ova." |
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发表于 2011-5-14 18:07:00
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