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Beer 中心转抄来的关于丈夫DQ alpha 201的资料 c- w+ `9 G% j# k: @
"A. DQ Alpha
- O) P' |7 p/ ^; z3 c2 D$ H- kThis test measures whether the DNA of the couple is too closely matched. These tests give you4 C- \! }9 o5 F
back two numbers for both members of the couple. In a normal pregnancy the father's DNA in0 f( k9 v ~! O8 c
the baby tells the mother's body to set up a protective reaction around the developing embryo. If1 B) I$ f4 s) ?; b( `; q2 H. ^
the father's DNA is too closely matched to the mother's, there is a good chance that the embryo' h/ |: b8 I& u% S
created by them is unable to differentiate itself from the mother's body. The mother's body then% M8 \3 j" w5 b: L
rejects the embryo because it cannot identify the embryo as a baby.) T: ^ l! h) S' x0 t
There are two different tests for the DQ, the Alpha and the Beta test. Most patients are only
3 ]& c& I+ }3 O0 V/ U5 x5 E: Ktested for the Alpha. The mother-to-be and the father-to-be get back two numbers (1.1, 1.2, 1.3,
7 I6 D9 w/ ~1 D1.4, 2, 3 or 4) one each from each of their respective parents (the baby-to-be's grandparents).
( @: v$ [8 Q/ o$ s0 b/ N, VAlthough there are breakdowns of the 2's, 3's and 4's, many people find that only the 1's are
. u! d- I* k- d0 k5 o% ~9 \significant, so they break those down to one more decimal. If both the mother-to-be's and the! x) \8 Z+ U) i' ]* H
father-to-be's DQ Alpha come back with a 4 DQ Alpha or the father-to-be's DQ Alpha comes
) ?* X6 K z7 s1 \1 q' R/ m3 ^: vback with a 2, a DQ Beta test is run. A DQ Alpha 2 translates into a DQ Alpha 201. The DQ
) l, X4 y/ R% y* ^/ smolecule also has a beta chain, and when the DQ Beta is 201, then this sperm will only produce
: h$ g6 C9 \1 J5 Q! b9 ja placenta, and not a baby. 89% of the people who test APA positive either have DQ Alpha 4 or
6 r' |5 U6 A* w& ~' T/ ^7 ?3 Aclosely matched DQ Alphas between partners. DQ Alpha compatibility is seen between mother
- z9 G* C7 U( D7 s7 r# f q8 T$ g3 land pregnancies that failed (through IVF failure or recurrent pregnancy loss). DQ incompatibility
$ ~! J) {3 S) F \5 d/ b1 ?between mother and baby was far more common in women successfully delivering babies.
4 f- B# P/ w1 P4 r. XDQ 201: If the father-to-be has a 2 in his DQ Alpha, 2% of the time a DQ Beta will show that it1 G# I+ ?% O6 x4 L [; T4 ]# [6 _. e
is also a DQ 201. Since the DQ 201 father-to-be has two DQ numbers, if only one of his
2 q8 ~ P% x$ ]! v* o I" U5 Bnumbers is the DQ 201, he has a 50/50 chance of producing an embryo that is DQ 201. If both of
+ F/ y4 ]' U0 B2 P# O/ Yhis numbers, both Alpha and Beta come back as 201, he has a 100% chance that all of his
$ O7 V' r. d X: o+ D, h9 [( [embryos will become blighted ova. The cure for this, when only one of his numbers is 201, is to i: e; @, }) L3 H1 H
put back more embryos to see if you can produce an embryo that is not DQ 201. If he has both% V8 v) J# d& O
numbers come back as a 201, the only option is donor sperm. 100% of DQ 201 embryos become1 m6 D! O, `. |4 P; _+ u
blighted ova." |
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发表于 2011-5-14 18:07:00
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