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引用第36023楼niuniu09于2009-07-29 11:28发表的 :
/ M) N* I# m t) L+ Esheen,你看看下面一段,
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HCG因其化学结构与LH相似,它们结合一共同的受体(LH/CG-R)而产生相似的生物学效应 [2],临床上常用来模拟内源性LH峰,促进卵泡的最后成熟及排卵,特别是对一些性腺 轴正反馈机制障碍的病人,以及用促性腺激素释放激素类似物促超排卵周期病人,HCG促排 卵的疗效是肯定的。本文结果显示,在缺乏内源性LH峰时应用HCG后排卵率达到内源性LH峰 后的自然排卵率。但应用HCG并未提高排卵率,分析主要与卵子是否成熟有关。所以在月经 中期应用HCG促排卵对存在缺乏内源性LH峰的排卵障碍病人是有效的。 niuniu 我昨天也找了一下文献,我用的方法是low-dose hCG protocol, 我正好昨天在老美的论坛上也看到有人用,不过很少。
! ]- ?' X: ]$ _6 T3 q; N5 b( p9 j# w你可以看看下面的这篇文章的摘要,, }7 z6 `' Y8 a+ v
我这次找的医生很注重成功率,感觉他对每个病人的用药都很小心的。不过目前为止我只见过他一次,其余都是跟护士打交道,感觉护士们也都挺好,我已经找了我认为最好的助孕中心,其余的就是看我的运气如何了。感觉自己在要孩子的事上运气实在不怎样,不知有没有转运的可能。尽人事,听天命吧。- R! u& n+ J8 q7 v6 M$ \2 y
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Abstract:
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Purpose: To examine the efficacy of low-dose hCG using a GnRH antagonist protocol./ H1 D+ Y; }" p/ w
# v: v5 |) O; `; v3 {$ iMethods: Prospective randomized study was performed at the Kyono Ladies Clinic. One hundred ninety-two women (<40 -years old, <3 previous cycles) were randomly assigned to GnRH agonist (buserelin) long protocol (LP, n = 66), GnRH antagonist (cetrorelix) with no low-dose hCG protocol (NhCGP, n = 63), or GnRH antagonist with low-dose hCG protocol (hCGP, n = 63).8 \( V. w9 C* R& ]. n
6 M# H: P; H3 A) Z3 E( P! T# HResults: The hCGP was associated with reduced total amounts of FSH, increased oocyte maturation rate, high-quality day 3 embryos rate, and number of frozen embryos. Ovarian hyperstimulation syndrome (OHSS) tended to be lower in the GnRH antagonist protocol. Pregnancy and implantation rates did not differ significantly between study groups.
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$ e: D& d; B" o. QConclusions: Daily low-dose hCG supplementation in the late follicular phase could improve the outcome in FSH based-GnRH antagonist protocol. This protocol, however, does require further modifications, including determination of the optimal doses for hCG and gonadotropin pretreatment. |
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